Description

D-Proline, 4-Fluoro-5-Oxo-, (4R)-Rel- (9Ci) CAS NO 32643-42-8 is a high-purity, non-natural amino acid derivative featuring a fluorinated oxoproline scaffold. This compound is a critical chiral building block and intermediate for the synthesis of complex pharmaceutical molecules, particularly in the development of protease inhibitors and other bioactive peptides. It is essential for research and production in advanced pharmaceutical chemistry, medicinal chemistry, and agrochemical research where precise stereochemistry and fluorination are required for modulating biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, especially protease inhibitors and peptide-based therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to investigate the impact of fluorination on peptide conformation, potency, and pharmacokinetic properties.
• Agrochemical Synthesis: Serves as a building block for creating advanced, bioactive molecules with potential herbicidal or insecticidal activity.
• Biochemical Tool Compound: Employed in enzymatic studies and as a probe to understand biological pathways involving proline metabolism or specific enzyme inhibition.
• Peptide Mimetic Development: Integral for designing and synthesizing peptidomimetics where the fluorinated oxoproline moiety enhances stability against degradation.
• Asymmetric Synthesis Catalyst: Potential use as a ligand or precursor for chiral catalysts in enantioselective transformations.

Basic Information

Product Name	D-Proline, 4-Fluoro-5-Oxo-, (4R)-Rel- (9Ci)
CAS No.	32643-42-8
Molecular Formula	C5H6FNO3
Molecular Weight	147.10 g/mol
Synonyms	(4R)-4-Fluoro-5-oxo-D-proline; 4-Fluoro-5-oxo-D-proline; (R)-4-Fluoro-5-oxopyrrolidine-2-carboxylic Acid; 4-Fluoro-5-oxo-L-proline (enantiomer); 4-Fluoro-5-oxoproline; 4-Fluoroprolinic acid; Fluorinated oxoproline derivative; D-4-Fluoro-5-oxoproline
EINECS	Contact for details

Quality Control

Our D-Proline, 4-Fluoro-5-Oxo-, (4R)-Rel- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.