Description

n-Heptafluorobutyrylimidazole is a highly reactive fluorinated acylating reagent, specifically an imidazole derivative of heptafluorobutyric acid. This compound is valued for its ability to efficiently introduce the perfluorinated butyryl group into target molecules, enhancing their lipophilicity and metabolic stability. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for derivatization, analytical chemistry, and the synthesis of specialty fluorinated compounds.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the preparation of fluorinated active pharmaceutical ingredients (APIs) and prodrugs to improve bioavailability and membrane permeability.
• Analytical Derivatization Agent: Used in Gas Chromatography (GC) and Mass Spectrometry (MS) for the analysis of amines, alcohols, and phenols, enhancing volatility and detection sensitivity.
• Agrochemical Production: Employed in the synthesis of novel fluorinated pesticides and herbicides, where the fluorine atoms contribute to increased efficacy and environmental persistence.
• Liquid Crystal & OLED Material Development: Serves as a building block for creating fluorinated components in electronic display materials, improving thermal and chemical stability.
• Peptide & Protein Modification: Facilitates the selective acylation of amino groups in peptides for research, diagnostics, and bioconjugation applications.
• Polymer Science: Used to incorporate perfluorinated side chains into polymers, imparting unique properties like oil and water repellency (surfactants, coatings).
• Cross-coupling Reagent: Acts as an activating agent in certain metal-catalyzed coupling reactions in fine chemical synthesis.

Basic Information

Product Name	n-Heptafluorobutyrylimidazole
CAS No.	32477-35-3
Molecular Formula	C7H3F7N2O
Molecular Weight	264.10 g/mol
Synonyms	Heptafluorobutyrylimidazole; 1H-Imidazole, 1-(heptafluorobutanoyl)-; 1-Heptafluorobutyrylimidazole; Perfluorobutyrylimidazole; HFBI; Imidazole, 1-(perfluorobutyryl)-; 1-(Perfluorobutyryl)imidazole; 1-(Heptafluorobutyryl)-1H-imidazole
EINECS	251-058-5

Quality Control

Our n-Heptafluorobutyrylimidazole is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and industrial synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management standards to support applications in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. Due to its reactivity as a fluoride/strong alkali-sensitive compound, ensure storage areas are free from moisture and alkaline contaminants.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.