Description

1-(1,1-Difluoroethyl)-4-Nitrobenzene is a specialized fluorinated aromatic compound featuring a nitro group and a difluoroethyl substituent. This unique molecular architecture makes it a valuable high-purity intermediate for advanced chemical synthesis, particularly in the development of novel active ingredients. It is primarily utilized by pharmaceutical R&D and agrochemical sectors for constructing complex molecules where fluorine incorporation is critical for modulating biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of fluorinated drug candidates, including potential kinase inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and pesticides where the difluoroethyl group enhances lipophilicity and metabolic stability.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, leveraging its aromatic and fluorinated characteristics.
• Organic Synthesis Reagent: Employed in cross-coupling reactions and nucleophilic aromatic substitution to introduce fluorinated aromatic segments.
• Fluorine Chemistry Studies: Acts as a model compound in academic and industrial research exploring the effects of gem-difluoroalkyl groups on aromatic system reactivity.

Basic Information

Product Name	1-(1,1-Difluoroethyl)-4-Nitrobenzene
CAS No.	32471-55-9
Molecular Formula	C8H7F2NO2
Molecular Weight	187.14 g/mol
Synonyms	4-Nitro-α,α-difluoroethylbenzene; 1-(1,1-Difluoroethyl)-4-nitrobenzene; p-Nitro(1,1-difluoroethyl)benzene; 1,1-Difluoro-1-(4-nitrophenyl)ethane; 4-Nitrophenyl-1,1-difluoroethyl; Benzene, 1-(1,1-difluoroethyl)-4-nitro-; (1,1-Difluoroethyl)-4-nitrobenzene
EINECS	Contact for details

Quality Control

Our 1-(1,1-Difluoroethyl)-4-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) documenting all critical parameters are provided with every shipment to guarantee traceability and consistency for your R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber packaging during storage and handling.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.