Description

5,12-Naphthacenedione, 8-Acetyl-10-3-(Acetylamino)-2,3,6-Trideoxy-.Alpha.-L-Lyxo-Hexopyranosyloxy-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-1-Methoxy-, (8S,10S)- is a complex, stereochemically defined anthracycline derivative with significant research and pharmaceutical development potential. This compound matters as a sophisticated chemical intermediate for the synthesis of novel bioactive molecules, particularly in oncology research. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on developing new therapeutic agents, especially anthracycline-based antibiotics and anticancer drugs.

Application

• Pharmaceutical Intermediate: Key building block in the research and synthesis of novel anthracycline-class chemotherapeutic agents.
• Oncology Research: Used in biochemical and pharmacological studies to investigate structure-activity relationships (SAR) for DNA intercalation and topoisomerase inhibition.
• Academic & R&D Laboratories: Serves as a reference standard and a precursor for medicinal chemistry programs targeting cancer and microbial infections.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses requiring a complex, functionalized tetracyclic core structure.
• Biochemical Tool Compound: Utilized in mechanistic studies to understand the action of glycosylated anthraquinones at the molecular level.

Basic Information

Product Name	5,12-Naphthacenedione, 8-Acetyl-10-3-(Acetylamino)-2,3,6-Trideoxy-.Alpha.-L-Lyxo-Hexopyranosyloxy-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-1-Methoxy-, (8S,10S)-
CAS No.	32385-10-7
Molecular Formula	C30H35NO13
Molecular Weight	617.60 g/mol
Synonyms	8-Acetyl-10-[3-(acetylamino)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; (8S,10S)-Isomer; Aclacinomycin A Aglycone Derivative; 2-Ethyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-4-ol; Related to Aclarubicin intermediate; Anthracycline derivative; 7-Deoxyaklavinone derivative; 32385-10-7
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical intermediates. We employ advanced analytical techniques including HPLC, NMR, and MS for identity confirmation and purity assessment. Certificates of Analysis (COA) detailing batch-specific results are available upon request. For custom synthesis projects, we adhere to GMP-like guidelines to ensure traceability and reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere to prevent potential degradation.

Specification

Item	Specification
Appearance	Yellow to Orange-Red Powder
Identification (HPLC)	Conforms to Reference Standard
Identification (NMR)	Conforms to Structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.