Description

R-Chlorpheniramine is the single enantiomer form of the widely used antihistamine chlorpheniramine, specifically the (R)-enantiomer. This high-purity chiral building block is critical for pharmaceutical research and development, offering superior selectivity and potency compared to the racemic mixture. It is primarily utilized by pharmaceutical manufacturers and advanced research institutions in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and for pharmacological studies.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of enantiopure antihistamine and antiallergy medications.
• Active Pharmaceutical Ingredient (API) Development: Used in R&D for developing new, more potent, and selective therapeutic agents with reduced side-effect profiles.
• Pharmacological Research: Essential reference standard and tool compound for studying histamine H1-receptor interactions, stereoselectivity, and metabolic pathways.
• Chiral Resolution Studies: Serves as a model compound in developing and validating methods for enantiomeric separation and analysis.
• Quality Control & Regulatory Standards: Used as a certified reference material (CRM) for assay calibration and impurity profiling in pharmaceutical quality control laboratories.

Basic Information

Product Name	R-Chlorpheniramine
CAS No.	32188-09-3
Molecular Formula	C16H19ClN2
Molecular Weight	274.79 g/mol
Synonyms	(R)-Chlorpheniramine; (+)-Chlorpheniramine; Dexchlorpheniramine enantiomer; (R)-1-(4-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane; (R)-γ-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine; (2R)-3-(4-Chlorophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine; AR-Chlorpheniramine; Dexchlorpheniramine Related Compound A
EINECS	Contact for details

Quality Control

Our R-Chlorpheniramine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets stringent specifications for pharmaceutical research. A Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and related substances is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (R-isomer)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.