Description

Dl-2,6-Difluorophenylalanine is a fluorinated non-natural amino acid derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in the unique electronic and steric properties imparted by the difluoro substitution on the phenyl ring, which can significantly alter the biological activity and metabolic stability of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel peptide mimetics, enzyme inhibitors, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new therapeutic agents, including protease inhibitors and receptor antagonists.
• Peptidomimetics & Drug Design: Used to incorporate fluorinated phenylalanine analogs into peptides to enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Serves as a building block for developing novel herbicides, fungicides, and plant growth regulators with improved efficacy.
• Biochemical Research: Employed in studies of enzyme mechanisms and protein engineering where fluorine acts as a probe or modulator of biological activity.
• Material Science: Potential precursor for specialty polymers and advanced materials requiring fluorinated aromatic components.
• Asymmetric Synthesis: Used as a starting material or resolving agent in the preparation of enantiomerically pure compounds for various applications.

Basic Information

Product Name	Dl-2,6-Difluorophenylalanine
CAS No.	32133-39-4
Molecular Formula	C9H9F2NO2
Molecular Weight	201.17 g/mol
Synonyms	DL-2,6-Difluorophenylalanine; (RS)-2-Amino-3-(2,6-difluorophenyl)propanoic acid; 2,6-Difluoro-DL-phenylalanine; DL-α-Amino-2,6-difluorohydrocinnamic acid; (±)-2-Amino-3-(2,6-difluorophenyl)propionic acid; DL-2,6-Difluoro-β-phenylalanine; 3-(2,6-Difluorophenyl)-DL-alanine; DL-2,6-F2Phe
EINECS	Contact for details

Quality Control

Our Dl-2,6-Difluorophenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing specific results for identity, purity, and impurities are provided with every shipment. We can support development projects with material produced under cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	DL-Racemate
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.