Description

11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 17-Benzoate is a synthetic corticosteroid derivative, specifically a 17-benzoate ester of a trihydroxylated pregnadiene structure. This compound is a critical pharmaceutical intermediate valued for its role in the synthesis of more complex, potent anti-inflammatory and immunosuppressive steroid APIs. It is primarily required by pharmaceutical R&D laboratories and manufacturers specializing in the production of advanced corticosteroid medications and novel steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent topical and systemic corticosteroids.
• Anti-inflammatory Drug Research: Used in the development and study of new steroid molecules with targeted therapeutic effects.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Process Chemistry: Employed in scale-up and optimization of steroid manufacturing processes within GMP environments.
• Biochemical Research: Utilized in studies investigating steroid receptor interactions and metabolic pathways.

Basic Information

Item	Detail
Product Name	11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 17-Benzoate
CAS No.	31311-74-7
Molecular Formula	C28H34O6
Molecular Weight	466.57 g/mol
Synonyms	Betamethasone 17-Benzoate; 9α-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17-benzoate (common mis-association); Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, 17-benzoate, (11β)-; 11β,17,21-Trihydroxypregna-1,4-diene-3,20-dione 17-benzoate; NSC 119185
EINECS	Contact for details

Quality Control

Our 11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 17-Benzoate is produced and tested under a strict quality management system. Each batch undergoes comprehensive analytical testing including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical intermediates. A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.