Description

3-Amino-5-(Trifluoromethyl)Benzonitrile is a high-value aromatic nitrile building block distinguished by its trifluoromethyl and amino functional groups. This compound matters for its role in facilitating the synthesis of complex molecules, particularly in the development of advanced pharmaceuticals and agrochemicals where the CF3 group is prized for its ability to modulate lipophilicity and metabolic stability. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Material Science Research: Employed in the synthesis of monomers and functional molecules for advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Useful in designing molecular probes and tags for studying biological systems and diagnostic applications.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving diverse R&D projects.

Basic Information

Product Name	3-Amino-5-(Trifluoromethyl)Benzonitrile
CAS No.	30825-34-4
Molecular Formula	C8H5F3N2
Molecular Weight	186.14 g/mol
Synonyms	5-Amino-3-(trifluoromethyl)benzonitrile; 3-Cyano-5-(trifluoromethyl)aniline; 3-Amino-α,α,α-trifluoro-m-toluonitrile; 3-(Trifluoromethyl)-5-cyanobenzenamine; m-Amino-α,α,α-trifluorobenzonitrile; Benzonitrile, 3-amino-5-(trifluoromethyl)-; 5-(Trifluoromethyl)-3-aminobenzonitrile
EINECS	Contact for details

Quality Control

Our 3-Amino-5-(Trifluoromethyl)Benzonitrile is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support compliance with cGMP, ISO, and REACH standards for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.