Description

Azatadine is a potent, long-acting antihistamine belonging to the tricyclic dibenzocycloheptene class. Its primary value lies in its high affinity for H1-receptors, making it a critical active pharmaceutical ingredient (API) for developing effective allergy and pruritus treatments. This compound is essential for pharmaceutical manufacturers and research institutions focused on producing or investigating antihistaminic medications, dermatological preparations, and novel therapeutic formulations.

Application

• Pharmaceutical API: Core active ingredient in prescription antihistamine tablets and syrups for the treatment of allergic conditions such as hay fever, urticaria, and allergic conjunctivitis.
• Antipruritic Formulations: Used in topical creams, ointments, or systemic medications to relieve itching associated with various dermatoses and skin allergies.
• Veterinary Pharmaceuticals: Incorporated into veterinary medicinal products for managing allergic reactions and pruritus in animals.
• Clinical Research: Serves as a reference standard and key intermediate in pharmacological studies and the development of new histamine H1-receptor antagonists.
• Drug Synthesis: Acts as a crucial chemical intermediate in the synthetic pathway for producing more complex or derivative antihistamine compounds.

Basic Information

Product Name	Azatadine
CAS No.	3964-81-6
Molecular Formula	C20H22N2
Molecular Weight	290.41 g/mol
Synonyms	Azatadine Maleate (Salt form); 11-(1-Methyl-4-piperidylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine; Idulamine; Optimine (brand name); Zadine; Lergocil; Trinalin (combination product); Azatadin
EINECS	223-567-4

Quality Control

Our Azatadine is manufactured under strict quality management systems, ensuring it meets the high-purity standards required for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling via HPLC and other pharmacopeial methods. A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.