Description

2,4-Difluorobenzonitrile is a versatile fluorinated aromatic nitrile building block essential for advanced organic synthesis. Its value lies in the strategic positioning of fluorine atoms on the benzene ring, which significantly influences the electronic properties and metabolic stability of final target molecules. This high-purity intermediate is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and liquid crystal material industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluorophenyl moiety to modulate bioavailability and binding affinity.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and pesticides where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in display technologies (LCDs).
• Organic Light-Emitting Diodes (OLEDs): Employed in the development of electron-transport materials and host materials for efficient OLED devices.
• Polymer Chemistry: Acts as a monomer or modifier in the production of specialty polymers with enhanced chemical resistance and thermal stability.
• Cross-Coupling Reactions: The nitrile group facilitates further functionalization via reactions like Suzuki-Miyaura or Sonogashira coupling, enabling complex molecular architecture construction.

Basic Information

Item	Detail
Product Name	2,4-Difluorobenzonitrile
CAS No.	3939-09-1
Molecular Formula	C7H3F2N
Molecular Weight	139.10 g/mol
Synonyms	2,4-Difluorobenzene carbonitrile; 2,4-Difluorophenyl cyanide; 2,4-DFBN; Benzonitrile, 2,4-difluoro-; 1-Cyano-2,4-difluorobenzene; 2,4-Difluorobenzonitrile; 3939-09-1 (CAS); 2,4-Difluorobenzyl nitrile (common misnomer)
EINECS	223-523-8

Quality Control

Our 2,4-Difluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizers, strong bases, and moisture. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.