Description

Streptonigrin CAS NO 3930-19-6 is a potent quinone-containing antibiotic and antitumor agent derived from *Streptomyces flocculus*. This compound is valued for its significant biological activity, primarily as a DNA intercalator and inhibitor of nucleic acid synthesis. It serves as a critical reference standard and active pharmaceutical ingredient (API) for research in oncology, microbiology, and biochemistry, supporting the development of novel therapeutic agents and diagnostic tools.

Application

• Oncology Research: Used as a reference standard and biochemical tool in studies of DNA damage, cell cycle arrest, and apoptosis mechanisms.
• Antimicrobial Studies: Employed in microbiological research to investigate its activity against various bacterial and fungal strains.
• Pharmaceutical Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the preclinical development of anticancer drugs.
• Biochemical Research: Utilized as a specific inhibitor in enzymatic assays and studies of topoisomerase function and nucleic acid metabolism.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in chemical biology and medicinal chemistry.

Basic Information

Product Name	Streptonigrin
CAS No.	3930-19-6
Molecular Formula	C25H22N4O8
Molecular Weight	506.47 g/mol
Synonyms	Bruneomycin; Nigrin; Antibiotic BA 163; Antibiotic NSC 45383; Rufochromomycin; 5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic acid; 2,2'-(-7-Amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinoly)-6-(2-hydroxy-3,4-dimethoxyphenyl)-5-methyl-3,4'-bipyridine-4-carboxylic acid
EINECS	223-516-8

Quality Control

Our Streptonigrin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, spectroscopic identification (IR, NMR), and residual solvent analysis, to ensure it meets high-purity standards suitable for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or under refrigeration (2-8°C) as specified. Due to its light-sensitive and easily oxidized nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	Dark brown to black crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.