Description

11Beta,17,21-Trihydroxypregn-4-Ene-3,20-Dione 21-(Dihydrogen Phosphate) is a key phosphorylated derivative of hydrocortisone, a vital corticosteroid. This compound is primarily valued as a high-purity pharmaceutical intermediate for the synthesis of more potent and bioavailable steroid-based therapeutics. It is essential for manufacturers and research institutions in the pharmaceutical and life sciences sectors engaged in developing anti-inflammatory, immunosuppressive, and hormonal medications.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced corticosteroid drugs, including prodrugs designed for enhanced delivery.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the manufacturing process of steroidal APIs for treating inflammatory and autoimmune conditions.
• Biochemical Research: Serves as a reference standard and a precursor in metabolic pathway studies and steroid hormone research.
• Prodrug Development: Its phosphate ester group is utilized to improve the water solubility and pharmacokinetic profile of parent steroid molecules.
• Veterinary Medicine: Employed in the development of steroidal treatments for animals.

Basic Information

Product Name	11Beta,17,21-Trihydroxypregn-4-Ene-3,20-Dione 21-(Dihydrogen Phosphate)
CAS No.	3863-59-0
Molecular Formula	C21H31O8P
Molecular Weight	442.44 g/mol
Synonyms	Cortisol 21-Phosphate; Hydrocortisone 21-Phosphate; 11β,17,21-Trihydroxypregn-4-ene-3,20-dione 21-(dihydrogen phosphate); Hydrocortisone Phosphate; NSC 10483; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, 21-(dihydrogen phosphate), (11β)-; Cortisol 21-(Dihydrogen Phosphate)
EINECS	223-389-1

Quality Control

Our 11Beta,17,21-Trihydroxypregn-4-Ene-3,20-Dione 21-(Dihydrogen Phosphate) is manufactured under strict quality management systems. We offer material suitable for pharmaceutical R&D and intermediate synthesis, with quality parameters typically aligned with in-house specifications for identity, purity, and related substances. Certificates of Analysis (COA) detailing lot-specific results from advanced analytical techniques like HPLC are provided with every shipment to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.