Description

3-Chloro-2,4-Difluoronitrobenzene is a high-purity, multi-functional aromatic intermediate of significant importance in advanced organic synthesis. Its unique structure, featuring chlorine, fluorine, and nitro substituents, makes it a versatile building block for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D chemists and process engineers in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluorophenyl or chlorophenyl motifs, used in various therapeutic areas.
• Agrochemical Synthesis: Employed in the manufacturing of advanced herbicides, fungicides, and insecticides, where the halogen and nitro groups are crucial for bioactivity.
• Liquid Crystal & OLED Material Production: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic display technologies.
• Polymer & Dye Intermediate: Used to introduce halogenated aromatic units into specialty polymers and high-performance dyes or pigments.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination to create complex biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and halogen groups allow for selective displacement with various nucleophiles, enabling diverse molecular derivatization.

Basic Information

Product Name	3-Chloro-2,4-Difluoronitrobenzene
CAS No.	3847-58-3
Molecular Formula	C6H2ClF2NO2
Molecular Weight	193.54 g/mol
Synonyms	1-Chloro-2,4-difluoro-3-nitrobenzene; 2,4-Difluoro-3-nitrochlorobenzene; 3-Nitro-2,4-difluorochlorobenzene; Benzene, 1-chloro-2,4-difluoro-3-nitro-; 3847-58-3; 3-Chloro-2,4-difluoro-1-nitrobenzene
EINECS	223-363-5

Quality Control

Our 3-Chloro-2,4-Difluoronitrobenzene is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates for regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.