Description

2-Methylcortisone is a synthetic corticosteroid derivative, a key intermediate in the synthesis of more complex steroidal pharmaceuticals. Its precise molecular structure allows for targeted modifications, making it a valuable building block in advanced organic and medicinal chemistry research. This compound is primarily utilized by the pharmaceutical industry for the development of novel anti-inflammatory and immunosuppressive agents, as well as by research institutions and fine chemical manufacturers.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potent corticosteroid drugs and other steroidal active pharmaceutical ingredients (APIs).
• Research & Development: Used in academic and industrial laboratories for studying structure-activity relationships (SAR) and developing new therapeutic compounds with modified glucocorticoid activity.
• Fine Chemical Synthesis: Serves as a specialized starting material or intermediate for custom synthesis and the production of high-value, low-volume specialty chemicals.
• Biochemical Research: Employed in metabolic studies and as a reference standard in analytical methods to understand corticosteroid pathways and interactions.

Basic Information

Item	Details
Product Name	2-Methylcortisone
CAS No.	3836-19-9
Molecular Formula	C23H30O5
Molecular Weight	386.48 g/mol
Synonyms	2α-Methylcortisone; 2-Methyl-17α,21-dihydroxypregn-4-ene-3,11,20-trione; 2-Methyl-11-dehydrocorticosterone; 2-Methyl-17,21-dihydroxypregn-4-ene-3,11,20-trione; 2α-Methyl-17α,21-dihydroxy-4-pregnene-3,11,20-trione; NSC 10483; 2-Methyl Compound S
EINECS	223-337-4

Quality Control

Our 2-Methylcortisone is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with key parameters including assay, related substances, and identification. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.