Description

2-Chloro-1,3-Difluoro-5-Nitro-Benzene is a high-purity, multi-functional halogenated nitrobenzene derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for research and development in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluorinated aromatic core.
• Agrochemical Synthesis: Used in the development of modern herbicides, fungicides, and pesticides, where the nitro and halogen groups are pivotal for bioactivity.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for producing complex azo dyes and other colorants.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Buchwald-Hartwig, and other C-N or C-O bond-forming processes.
• Organic Synthesis Building Block: Utilized in nucleophilic aromatic substitution (SNAr) reactions due to the activated chlorine and fluorine atoms ortho and para to the nitro group.

Basic Information

Product Name	2-Chloro-1,3-Difluoro-5-Nitro-Benzene
CAS No.	3828-41-9
Molecular Formula	C6H2ClF2NO2
Molecular Weight	193.54 g/mol
Synonyms	1-Chloro-2,4-difluoro-5-nitrobenzene; 2,4-Difluoro-1-chloro-5-nitrobenzene; 5-Nitro-1-chloro-2,4-difluorobenzene; 2-Chloro-1,3-difluoro-5-nitrobenzene; Benzene, 2-chloro-1,3-difluoro-5-nitro-; 3828-41-9 (CAS); 2,4-Difluoronitrochlorobenzene
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for all our chemical intermediates. Production of 2-Chloro-1,3-Difluoro-5-Nitro-Benzene adheres to current Good Manufacturing Practices (cGMP) where applicable, ensuring batch-to-batch consistency and reliability. Every lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, available upon request. Our quality systems are designed to meet the exacting standards of the pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases, reducing agents, and sources of ignition. For long-term storage, consider under an inert atmosphere to maintain purity.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.