Description

Acetyloxy Diflorasone CAS NO 3826-17-3 is a synthetic corticosteroid derivative, specifically a diester of diflorasone. This compound is a key pharmaceutical intermediate of significant value in the development and manufacturing of topical anti-inflammatory and antipruritic medications. It is primarily utilized by pharmaceutical R&D departments and active pharmaceutical ingredient (API) manufacturers. The compound's structure allows for targeted modifications to optimize potency and bioavailability in final drug formulations.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of high-potency topical corticosteroids like Diflorasone Diacetate.
• Research & Development: Serves as a reference standard and starting material in medicinal chemistry for developing new dermatological therapeutics.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the controlled production of bulk APIs for anti-inflammatory creams, ointments, and lotions.
• Dermatological Formulations: Integral to creating formulations aimed at treating conditions such as eczema, psoriasis, and contact dermatitis.
• Analytical Standard: Employed in quality control laboratories for HPLC, GC, or spectroscopic assay development and validation.

Basic Information

Product Name	Acetyloxy Diflorasone
CAS No.	3826-17-3
Molecular Formula	C₂₆H₃₂F₂O₇
Molecular Weight	494.53 g/mol
Synonyms	6α,9-Difluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-diacetate; Diflorasone 17,21-Diacetate; 6α,9-Difluoro-11β-hydroxy-16β-methyl-17,21-bis(acetyloxy)pregna-1,4-diene-3,20-dione; NSC 119281; SQ-15102; 17,21-Diacetoxy-6α,9-difluoro-11β-hydroxy-16β-methylpregna-1,4-diene-3,20-dione
EINECS	223-322-6

Quality Control

Our Acetyloxy Diflorasone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents are provided with every shipment. We adhere to cGMP guidelines where applicable to support our clients' regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.