Description

6-Fluoro-17,21-Dihydroxypregna-4,9(11)-Diene-3,20-Dione 17,21-Diacetate is a high-purity fluorinated steroid intermediate of significant importance in advanced pharmaceutical synthesis. This compound is valued for its role as a key building block in the development of potent corticosteroid and anti-inflammatory APIs. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of specialized steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potent fluorinated corticosteroids, such as dexamethasone and betamethasone derivatives.
• Anti-inflammatory Drug Research: Serves as a key scaffold in the discovery and development of novel steroidal anti-inflammatory agents with enhanced potency and selectivity.
• Hormone Analog Synthesis: Used in the preparation of synthetic analogs of pregnane-based hormones for therapeutic and research applications.
• Process Chemistry: Employed in process development and scale-up activities for established steroid APIs, enabling efficient and high-yield manufacturing routes.
• Reference Standard: Utilized as a high-purity analytical reference standard for quality control and regulatory testing of related steroid products.

Basic Information

Product Name	6-Fluoro-17,21-Dihydroxypregna-4,9(11)-Diene-3,20-Dione 17,21-Diacetate
CAS No.	3821-34-9
Molecular Formula	C₂₅H₃₁FO₆
Molecular Weight	446.51 g/mol
Synonyms	6-Fluoro-17α,21-dihydroxypregna-4,9(11)-diene-3,20-dione 17,21-diacetate; 6-Fluoro-δ⁹(11)-pregnenolone 17,21-diacetate; 6-Fluoro-11-dehydrocorticosterone 17,21-diacetate; 6-Fluoro-17,21-diacetoxypregna-4,9(11)-diene-3,20-dione; 6-Fluoro-11-dehydrocorticosterone acetate; 3821-34-9; 6-Fluoro-δ⁹(11)-corticosterone 17,21-diacetate
EINECS	Contact for details

Quality Control

Our 6-Fluoro-17,21-Dihydroxypregna-4,9(11)-Diene-3,20-Dione 17,21-Diacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR, to ensure it meets the stringent requirements for pharmaceutical intermediate use. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.