Description

2,2,3,3,3-Pentafluoro-Propionamidine Hcl is a high-purity fluorinated amidine hydrochloride salt, a key building block in advanced organic synthesis. This compound is valued for its ability to introduce the pentafluoroethyl group, a moiety known to significantly enhance the metabolic stability, lipophilicity, and bioavailability of target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated drug candidates, particularly for antiviral, anticancer, and central nervous system (CNS) targeted therapies.
• Agrochemical Synthesis: Used to construct advanced fluorinated herbicides, fungicides, and insecticides, where the fluorine atoms improve weather resistance and biological activity.
• Material Science Research: Serves as a monomer or modifying agent in the development of specialty polymers and coatings with unique surface properties and chemical resistance.
• Ligand and Catalyst Development: Employed in the creation of novel nitrogen-donor ligands for catalytic systems and metal-organic frameworks (MOFs).
• Fluorinated Probe Synthesis: Utilized in medicinal chemistry and chemical biology to create fluorinated molecular probes and imaging agents for diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A fundamental building block for custom chemical synthesis services targeting high-value, complex fluorinated molecules.

Basic Information

Item	Details
Product Name	2,2,3,3,3-Pentafluoro-Propionamidine Hydrochloride
CAS No.	3799-21-1
Molecular Formula	C3H4ClF5N2
Molecular Weight	198.52 g/mol
Synonyms	Pentafluoropropionamidine Hydrochloride; 2,2,3,3,3-Pentafluoropropanimidamide Hydrochloride; 3,3,3-Trifluoro-2-(trifluoromethyl)propanimidamide Hydrochloride; PFPAmidine HCl; Amidino-Pentafluoropropane HCl; 3799-21-1; 2,2,3,3,3-Pentafluoropropionimidic acid amide hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 2,2,3,3,3-Pentafluoro-Propionamidine HCl is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.