Description

Dexamethasone 21-Propionate is a potent synthetic glucocorticoid ester derivative, widely recognized for its enhanced lipophilicity and anti-inflammatory activity. This compound is a critical intermediate and active pharmaceutical ingredient (API) in the development of advanced topical and injectable corticosteroid formulations. It is essential for pharmaceutical manufacturers and research institutions focused on dermatology, ophthalmology, and other therapeutic areas requiring targeted corticosteroid delivery.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of high-potency topical corticosteroids for creams, ointments, and lotions.
• Active Pharmaceutical Ingredient (API): Used in the formulation of injectable and implantable steroid preparations for sustained anti-inflammatory action.
• Ophthalmic Preparations: Employed in the development of eye drops and ointments for treating inflammatory eye conditions.
• Veterinary Medicine: Utilized in anti-inflammatory and immunosuppressive treatments for animals.
• Research & Development: Serves as a reference standard and a crucial compound in pharmacological studies of glucocorticoid receptor activity and drug metabolism.
• Dermatological Products: Found in prescription-strength treatments for psoriasis, eczema, and other severe skin inflammations.

Basic Information

Product Name	Dexamethasone 21-Propionate
CAS No.	3793-10-0
Molecular Formula	C24H33FO6
Molecular Weight	436.52 g/mol
Synonyms	Dexamethasone 21-propanoate; 9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-propionate; 16α-Methyl-9α-fluoro-1,4-pregnadiene-11β,17α,21-triol-3,20-dione 21-propionate; Dexamethasone Propionate; NSC-123011; Dexpropionate; Flucort
EINECS	223-273-4

Quality Control

Our Dexamethasone 21-Propionate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and NMR spectroscopy, and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) compliant with cGMP and ICH Q7 guidelines to support regulatory filings for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	+77° to +83° (c=1 in dioxane)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.