Description

17,21-Dihydroxy-5Alpha-Pregnane-3,11,20-Trione 21-Acetate is a high-purity steroid derivative and a key synthetic intermediate in the production of more complex corticosteroid and hormone-based active pharmaceutical ingredients (APIs). Its value lies in providing a reliable and well-characterized building block for pharmaceutical R&D and manufacturing, ensuring consistent quality and predictable reaction outcomes. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly those developing or producing anti-inflammatory, hormonal, or other steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of corticosteroid drugs and other steroidal APIs.
• Research & Development: Used in medicinal chemistry for the discovery and structural modification of new steroid-based therapeutic agents.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial production of steroid hormones.
• Biochemical Research: Utilized in studies investigating steroid metabolism, receptor interactions, and enzymatic pathways.

Basic Information

Product Name	17,21-Dihydroxy-5Alpha-Pregnane-3,11,20-Trione 21-Acetate
CAS No.	3751-02-8
Molecular Formula	C23H32O7
Molecular Weight	420.50 g/mol
Synonyms	21-Acetoxy-5α-pregnane-3,11,20-trione-17α,21-diol; 17α,21-Dihydroxy-5α-pregnane-3,11,20-trione 21-acetate; 5α-Pregnane-3,11,20-trione, 17,21-dihydroxy-, 21-acetate; 11-Dehydrocorticosterone 21-acetate; Reichstein's Substance Q 21-Acetate; 21-Acetoxypregnane-3,11,20-trione-17α,21-diol; 17α-Hydroxy-11-dehydrocorticosterone 21-acetate
EINECS	Contact for details

Quality Control

Our 17,21-Dihydroxy-5Alpha-Pregnane-3,11,20-Trione 21-Acetate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and specific tests for residual solvents and related substances. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with the stringent requirements of pharmaceutical development and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.