Description

(S)-1,1,1-Trifluoro-2-Propanol is a high-purity, chiral fluorinated alcohol building block of significant importance in advanced organic synthesis. Its value lies in its ability to introduce a trifluoromethyl group and a chiral center, which are crucial for modulating the physical, chemical, and biological properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors who require enantiomerically pure intermediates for the development of active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethylated stereogenic center.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the (S)-enantiomer provides specific biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Employed in the development of specialty polymers, liquid crystals, and fluorinated materials with unique surface properties and stability.
• Analytical Chemistry: Can be used as a chiral derivatizing agent or a standard for chromatographic analysis.

Basic Information

Product Name	(S)-1,1,1-Trifluoro-2-Propanol
CAS No.	3539-97-7
Molecular Formula	C3H5F3O
Molecular Weight	114.07 g/mol
Synonyms	(S)-1,1,1-Trifluoro-2-propanol; (S)-2-Trifluoromethyl ethanol; (S)-1,1,1-Trifluoroisopropanol; (S)-TFIP; (S)-α-Trifluoromethyl ethanol; (S)-Hexafluoroisopropanol enantiomer (related); (S)-2-Hydroxy-1,1,1-trifluoropropane; (S)-TFP
EINECS	222-576-5

Quality Control

Our (S)-1,1,1-Trifluoro-2-Propanol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by GC or HPLC, to ensure it meets the high standards required for synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, enantiomeric excess, and key physical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Enantiomeric Excess (Chiral GC/HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.300 - 1.320
Specific Rotation ([α]20D)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.