Description

Hydrocortisone 11,17,21-Triacetate is a key acetylated derivative of the natural glucocorticoid hormone hydrocortisone. This modification enhances its stability and alters its pharmacokinetic profile, making it a valuable intermediate in the synthesis of more complex steroid-based pharmaceuticals. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development and production of corticosteroid medications, including topical creams and other therapeutic formulations.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of more potent or targeted corticosteroid drugs.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of corticosteroid products.
• Biochemical Research: Employed in studies investigating glucocorticoid receptor activity, steroid metabolism, and anti-inflammatory pathways.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a direct precursor in the production of certain corticosteroid APIs for topical and systemic use.
• Veterinary Medicine: Used in the development of anti-inflammatory and immunosuppressive treatments for animals.

Basic Information

Product Name	Hydrocortisone 11,17,21-Triacetate
CAS No.	3517-51-9
Molecular Formula	C27H36O8
Molecular Weight	488.57 g/mol
Synonyms	Cortisol 11,17,21-Triacetate; Hydrocortisone Triacetate; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 11,17,21-Triacetate; 11β,17α,21-Triacetoxypregn-4-ene-3,20-dione; NSC 10483; Cortisol Triacetate; 11,17,21-Triacetylcortisol
EINECS	222-507-1

Quality Control

Our Hydrocortisone 11,17,21-Triacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting high standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing specific results for assay, related substances, and residual solvents are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.