Description

5-Fluoro-2-Nitrophenylacetonitrile is a versatile aromatic nitrile building block characterized by its distinct fluorine and nitro substituents. This compound is valued for its role as a key synthetic intermediate in the development of complex organic molecules, particularly in pharmaceutical and agrochemical research. It is essential for chemists and manufacturers in the fine chemical, pharmaceutical, and advanced material sectors who require high-purity intermediates for constructing heterocyclic compounds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the fluorine atom enhances biological activity and environmental stability.
• Material Science Research: Serves as a building block for creating specialized polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate in the production of complex, high-performance dyes and pigments.
• Cross-Coupling Reactions: The nitrile and nitro groups make it a suitable substrate for palladium-catalyzed cross-coupling reactions, such as Suzuki and Heck reactions.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic pathways and creating compound libraries for screening.

Basic Information

Product Name	5-Fluoro-2-Nitrophenylacetonitrile
CAS No.	3456-75-5
Molecular Formula	C8H5FN2O2
Molecular Weight	180.14 g/mol
Synonyms	2-(5-Fluoro-2-nitrophenyl)acetonitrile; (5-Fluoro-2-nitrophenyl)acetonitrile; 5-Fluoro-2-nitrobenzyl cyanide; α-Cyano-5-fluoro-2-nitro toluene; 3456-75-5; 5-Fluoro-2-nitrobenzeneacetonitrile; 2-Nitro-5-fluorophenylacetonitrile
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Nitrophenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be amber-colored or stored in a dark place.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.