Description

Streptonigrin is a potent, naturally occurring quinone antibiotic and antitumor agent isolated from *Streptomyces flocculus*. Its primary value lies in its ability to function as a DNA intercalator and topoisomerase II inhibitor, inducing significant DNA damage in target cells. This mechanism makes it a critical research compound for oncology studies, antimicrobial research, and the development of novel chemotherapeutic agents. Researchers and pharmaceutical developers in the life sciences sector rely on high-purity Streptonigrin CAS NO 3398-48-9 for investigative and preclinical applications.

Application

• Anticancer Research: Used as a reference standard and active agent in studies targeting DNA replication and topoisomerase II function in various cancer cell lines.
• Antimicrobial Studies: Investigated for its activity against bacteria, fungi, and protozoa due to its potent antibiotic properties.
• Biochemical Mechanism Studies: Employed to study oxidative stress, DNA damage pathways, and apoptosis (programmed cell death) in cellular models.
• Pharmaceutical Development: Serves as a lead compound or molecular scaffold in the discovery and synthesis of new chemotherapeutic agents.
• Academic & Institutional Research: Utilized in universities and research institutes for fundamental studies in biochemistry, molecular biology, and pharmacology.

Basic Information

Product Name	Streptonigrin
CAS No.	3398-48-9
Molecular Formula	C₂₅H₂₂N₄O₈
Molecular Weight	506.47 g/mol
Synonyms	Bruneomycin; Nigrin; Antibiotic BA 163; Antibiotic NSC 45383; Rufochromomycin; 5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic acid
EINECS	Contact for details

Quality Control

Our Streptonigrin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research purposes. Each lot undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent internal specifications. We support research requiring traceable, high-quality biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider conditions recommended for light-sensitive compounds.

Specification

Item	Specification
Appearance	Dark brown to black crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.