Description

11-Beta,21-Dihydroxy-6-α-Methylpregna-4,17(20)-Dien-3-One is a high-purity steroid intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters for its role as a critical building block in the production of potent corticosteroid and other steroidal APIs, enabling precise molecular modifications. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for developing next-generation anti-inflammatory and immunosuppressive therapies, where its defined stereochemistry is essential for biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of advanced corticosteroid active pharmaceutical ingredients (APIs).
• Steroid Research & Development: Used in medicinal chemistry for the design and development of novel steroidal compounds with targeted therapeutic effects.
• Process Chemistry: Serves as a defined starting material or intermediate in GMP-compliant manufacturing processes for regulated drugs.
• Reference Standard: Can be utilized as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Biochemical Studies: Employed in research to study steroid hormone receptor interactions and metabolic pathways.

Basic Information

Product Name	11-Beta,21-Dihydroxy-6-α-Methylpregna-4,17(20)-Dien-3-One
CAS No.	3386-04-7
Molecular Formula	C22H30O3
Molecular Weight	342.47 g/mol
Synonyms	6α-Methyl-11β,21-dihydroxypregna-4,17(20)-dien-3-one; 6α-Methyl-11β,21-dihydroxy-4,17(20)-pregnadien-3-one; 11β,21-Dihydroxy-6α-methylpregna-4,17(20)-dien-3-one; 6α-Methylprednisolone 17(20)-dehydro Intermediate; Prednisolone Related Compound; 3386-04-7
EINECS	Contact for details

Quality Control

Our 11-Beta,21-Dihydroxy-6-α-Methylpregna-4,17(20)-Dien-3-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing identity, purity, and impurity profiles as determined by advanced analytical techniques like HPLC and NMR. Our quality commitment aligns with ICH guidelines, and we support customer audits and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.