Description

17-Beta Hydroxy Exemestane is a key pharmaceutical intermediate and metabolite of the aromatase inhibitor exemestane. This compound is critical for research and development in the synthesis of advanced steroidal therapeutics. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on oncology, endocrinology, and analytical method development.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of the active pharmaceutical ingredient (API) exemestane and related steroidal compounds.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method validation, quality control, and impurity profiling of exemestane API and finished dosage forms.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to study the metabolism, bioavailability, and biological activity of exemestane.
• Biochemical Research: Employed in vitro and in vivo studies to investigate aromatase inhibition mechanisms and structure-activity relationships (SAR) of steroidal inhibitors.
• Process Development: Serves as a key intermediate for optimizing and scaling up manufacturing processes for exemestane under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	17-Beta Hydroxy Exemestane
CAS No.	3347-73-7
Molecular Formula	C20H24O2
Molecular Weight	296.40 g/mol
Synonyms	6-Methylenandrosta-1,4-diene-3,17-dione, 17-Hydroxy Derivative; 17β-Hydroxy-6-methylenandrosta-1,4-diene-3-one; 17-Hydroxy Exemestane; Exemestane 17β-Hydroxy Metabolite; 6-Methylenandrosta-1,4-diene-3,17-diol, 17β-isomer; Aromasin Metabolite; FCE 24304 Hydroxy Derivative
EINECS	Contact for details

Quality Control

Our 17-Beta Hydroxy Exemestane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and NMR spectroscopy, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) that detail all specifications and test results, ensuring compliance with research and pharmaceutical intermediate standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.