Description

3,5-Dichloro-4-Fluoronitrobenzene is a versatile halogenated nitrobenzene derivative that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active ingredients, dyes, and functional materials who require a reliable supply of high-purity intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules containing fluorinated and chlorinated aromatic systems.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides, where the halogen atoms contribute to biological activity and stability.
• Dye and Pigment Manufacturing: Serves as a starting material for synthesizing complex organic dyes and pigments, leveraging the nitro group for further functionalization.
• Material Science Research: Employed in the development of advanced polymers, liquid crystals, and electronic materials that require specific halogenated aromatic monomers.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and halogen groups make it reactive in SNAr reactions for introducing various nucleophiles.

Basic Information

Product Name	3,5-Dichloro-4-Fluoronitrobenzene
CAS No.	3107-19-5
Molecular Formula	C6H2Cl2FNO2
Molecular Weight	209.99 g/mol
Synonyms	1,3-Dichloro-2-fluoro-5-nitrobenzene; 2-Fluoro-1,3-dichloro-5-nitrobenzene; 4-Fluoro-3,5-dichloronitrobenzene; Benzene, 1,3-dichloro-2-fluoro-5-nitro-; 3,5-Dichloro-4-fluoronitrobenzene; 3107-19-5; NSC 406106
EINECS	221-467-7

Quality Control

Our 3,5-Dichloro-4-Fluoronitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	64 - 68 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.