Description

9,21-Difluoro-11β-Hydroxy-16α,17-[(1-Methylethylidene)Bisoxy]Pregna-1,4-Diene-3,20-Dione is a high-purity synthetic corticosteroid derivative, recognized for its potent anti-inflammatory and immunosuppressive activity. Its value lies in its role as a critical pharmaceutical intermediate for the synthesis of advanced topical and systemic steroid medications. This compound is essential for pharmaceutical R&D and manufacturing sectors focused on developing next-generation therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potent topical corticosteroids like Diflorasone Diacetate.
• Active Pharmaceutical Ingredient (API) Development: Used in research and production of novel anti-inflammatory and immunosuppressive drugs.
• Dermatological Preparations: Serves as a precursor for APIs used in creams, ointments, and lotions for treating eczema, psoriasis, and dermatitis.
• Steroid Prodrug Synthesis: Utilized in creating prodrugs with enhanced bioavailability and targeted delivery.
• Biochemical Research: Employed in studies investigating glucocorticoid receptor interactions and steroid metabolism pathways.
• Veterinary Pharmaceuticals: Potential use in developing anti-inflammatory treatments for animals.

Basic Information

Product Name	9,21-Difluoro-11β-Hydroxy-16α,17-[(1-Methylethylidene)Bisoxy]Pregna-1,4-Diene-3,20-Dione
CAS No.	3093-22-9
Molecular Formula	C24H30F2O5
Molecular Weight	436.49 g/mol
Synonyms	Diflorasone Acetonide; 9α,21-Difluoro-11β-hydroxy-16α,17α-isopropylidenedioxypregna-1,4-diene-3,20-dione; 9α,21-Difluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone; Diflorasone-16,17-acetonide; NSC 121055; SQ-15102; Pregna-1,4-diene-3,20-dione, 9,21-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11β,16α)-
EINECS	Contact for details

Quality Control

Our 9,21-Difluoro-11β-Hydroxy-16α,17-[(1-Methylethylidene)Bisoxy]Pregna-1,4-Diene-3,20-Dione is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications for pharmaceutical intermediate use. Certificates of Analysis (COA) documenting purity, related substances, and residual solvents are available upon request, supporting compliance with cGMP and global regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.