Description

11Beta,21-Dihydroxypregna-1,4,16-Triene-3,20-Dione 21-Acetate is a high-purity steroid derivative with significant importance in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of potent glucocorticoids and other specialized therapeutic agents. It is primarily sought by pharmaceutical manufacturers and research institutions engaged in the development of anti-inflammatory, immunosuppressive, and oncological treatments.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced corticosteroid drugs, including potent topical and systemic anti-inflammatory agents.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of novel glucocorticoid receptor modulators.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for complex steroid-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Utilized in studies investigating glucocorticoid receptor signaling pathways and related metabolic processes.

Basic Information

Product Name	11Beta,21-Dihydroxypregna-1,4,16-Triene-3,20-Dione 21-Acetate
CAS No.	3044-42-6
Molecular Formula	C23H28O6
Molecular Weight	400.47 g/mol
Synonyms	21-Acetoxy-11β,21-dihydroxypregna-1,4,16-triene-3,20-dione; 11β,21-Dihydroxy-1,4,16-pregnatriene-3,20-dione 21-acetate; Prednisolone 21-acetate derivative; 1,4,16-Pregnatriene-11β,21-diol-3,20-dione 21-acetate; 11β-Hydroxyprednisolone 21-acetate; 16-Dehydro-11β-hydroxyprednisolone 21-acetate; NSC 10483
EINECS	Contact for details

Quality Control

Our 11Beta,21-Dihydroxypregna-1,4,16-Triene-3,20-Dione 21-Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment to ensure compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.