Description

3-Fluoro-4-Nitro-o-Xylene is a specialized aromatic intermediate of significant importance in advanced organic synthesis. Its core value lies in the strategic positioning of its functional groups, which make it a versatile building block for constructing complex molecular architectures. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides, pesticides, and fungicides, where the fluorine atom enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for synthesizing complex, high-performance fluorinated dyes and pigments with unique color fastness and spectral properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create biaryl structures common in many functional molecules.
• Nucleophilic Aromatic Substitution: The nitro and fluoro groups provide reactive sites for selective substitution, enabling the introduction of various amines, alkoxides, and other nucleophiles.

Basic Information

Item	Detail
Product Name	3-Fluoro-4-Nitro-o-Xylene
CAS No.	3013-30-7
Molecular Formula	C8H8FNO2
Molecular Weight	169.15 g/mol
Synonyms	1,2-Dimethyl-3-fluoro-4-nitrobenzene; 3-Fluoro-4-nitro-1,2-dimethylbenzene; 2,3-Dimethyl-6-fluoro-1-nitrobenzene; o-Xylene, 3-fluoro-4-nitro-; 3-Fluoro-4-nitro-o-xylene; 4-Nitro-3-fluoro-1,2-dimethylbenzene; 6-Fluoro-2,3-dimethylnitrobenzene; 3013-30-7
EINECS	221-138-5

Quality Control

Our 3-Fluoro-4-Nitro-o-Xylene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.