Description

4-Methoxy-3-Nitrobenzotrifluoride is a versatile fluorinated aromatic building block, primarily valued for its role as a key intermediate in the synthesis of advanced agrochemicals and pharmaceuticals. Its unique trifluoromethyl and nitro-substituted methoxybenzene structure makes it essential for introducing specific functionalities into target molecules. This compound is particularly sought after by R&D chemists and process development teams in the fine chemical, crop protection, and pharmaceutical industries.

Application

• Agrochemical Intermediate: A critical precursor in the synthesis of modern herbicides and pesticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Pharmaceutical Synthesis: Serves as a key building block for active pharmaceutical ingredients (APIs), especially in the development of molecules with improved metabolic stability and bioavailability.
• Liquid Crystal & OLED Materials: Used in the research and production of advanced electronic materials, where its aromatic and fluorinated structure contributes to desired electronic and optical properties.
• Dye & Pigment Manufacturing: Acts as an intermediate for synthesizing specialized dyes and pigments, leveraging its nitro and methoxy functional groups.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Functional Material Research: Employed in academic and industrial R&D for developing novel polymers, ligands, and sensors.

Basic Information

Product Name	4-Methoxy-3-Nitrobenzotrifluoride
CAS No.	394-25-2
Molecular Formula	C8H6F3NO3
Molecular Weight	221.14 g/mol
Synonyms	1-Methoxy-2-nitro-4-(trifluoromethyl)benzene; 3-Nitro-4-methoxybenzotrifluoride; 4-Methoxy-3-nitro-α,α,α-trifluorotoluene; 2-Nitro-4-(trifluoromethyl)anisole; 4-(Trifluoromethyl)-2-nitroanisole; NSC 404071; Benzene, 1-methoxy-2-nitro-4-(trifluoromethyl)-
EINECS	206-902-3

Quality Control

Our 4-Methoxy-3-Nitrobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for industrial and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.