Description

2,4-Dichloro-3-Fluoronitrobenzene is a versatile halogenated nitrobenzene derivative that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable precursor for the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. This intermediate is essential for researchers and manufacturers involved in creating active pharmaceutical ingredients (APIs), crop protection agents, and specialty dyes.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug molecules, particularly those containing fluorinated and chlorinated aromatic systems.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and stability.
• Dye and Pigment Manufacturing: Serves as a starting material for producing specialized colorants and functional dyes.
• Material Science Research: Employed in the development of novel organic electronic materials and liquid crystals.
• Cross-Coupling Reactions: A valuable substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and halogen groups make it an excellent candidate for displacement reactions to introduce various functional groups.

Basic Information

Product Name	2,4-Dichloro-3-Fluoronitrobenzene
CAS No.	393-79-3
Molecular Formula	C6H2Cl2FNO2
Molecular Weight	209.99 g/mol
Synonyms	1,2-Dichloro-4-fluoro-5-nitrobenzene; 3-Fluoro-2,4-dichloronitrobenzene; 2,4-Dichloro-3-fluoronitrobenzene; 5-Nitro-1,2-dichloro-4-fluorobenzene; Benzene, 1,2-dichloro-4-fluoro-5-nitro-; 2,4-Dichloro-3-fluoronitrobenzol; NSC 403108
EINECS	206-894-4

Quality Control

Our 2,4-Dichloro-3-Fluoronitrobenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be opaque or stored in dark conditions.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.