Description

5-Fluoro-2-Nitrobenzotrifluoride is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring both a nitro and a trifluoromethyl group on a fluorinated benzene ring, makes it a critical intermediate for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to introduce fluorine atoms and functionalized aromatic systems into target compounds to modulate their biological activity, metabolic stability, and physical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic cores to enhance bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the development of modern herbicides, fungicides, and insecticides, where the trifluoromethyl and nitro groups contribute to efficacy and environmental profile.
• Material Science Research: Serves as a monomer or building block for creating specialty polymers, liquid crystals, and organic electronic materials with specific optical or electronic properties.
• Dye and Pigment Manufacturing: Employed in the synthesis of advanced fluorinated dyes and pigments that offer superior lightfastness and color stability.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl structures.
• Nucleophilic Aromatic Substitution: The nitro and fluorine groups make it reactive in SNAr reactions, allowing for the introduction of various nucleophiles.

Basic Information

Product Name	5-Fluoro-2-Nitrobenzotrifluoride
CAS No.	393-09-9
Molecular Formula	C7H3F4NO2
Molecular Weight	209.10 g/mol
Synonyms	1-Fluoro-4-nitro-2-(trifluoromethyl)benzene; 2-Nitro-5-fluorobenzotrifluoride; 5-Fluoro-2-nitro-α,α,α-trifluorotoluene; 2-Nitro-α,α,α,5-tetrafluorotoluene; Benzene, 1-fluoro-4-nitro-2-(trifluoromethyl)-; 4-Fluoro-3-(trifluoromethyl)nitrobenzene; 5-Fluoro-2-nitrobenzylidene trifluoride
EINECS	206-882-7

Quality Control

Our 5-Fluoro-2-Nitrobenzotrifluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for fine chemical intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We can support development and production needs across various grades, from research quantities to commercial scale.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and reducing agents. Recommended storage temperature is between 2°C and 25°C. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.