Description

11β,17α,20β,21-Tetrahydroxy-6α-Methylpregna-1,4-Diene-3-One is a high-purity synthetic corticosteroid intermediate of significant commercial and pharmaceutical importance. This compound serves as a critical precursor in the synthesis of potent glucocorticoids, valued for its specific stereochemistry and functional groups. It is primarily required by pharmaceutical R&D laboratories and manufacturing facilities engaged in the production of advanced anti-inflammatory and immunosuppressive steroid APIs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of methylprednisolone and related corticosteroid drugs.
• Research & Development: Used in medicinal chemistry for the development of new glucocorticoid receptor agonists with modified potency and metabolic profiles.
• Reference Standard: Serves as an analytical standard in quality control laboratories for HPLC or LC-MS method development and validation.
• Process Chemistry: Employed in scale-up and optimization studies for the industrial manufacturing of steroid-based therapeutics.
• Biochemical Research: Utilized in studies investigating steroid hormone action, receptor binding, and metabolic pathways.

Basic Information

Product Name	11β,17α,20β,21-Tetrahydroxy-6α-Methylpregna-1,4-Diene-3-One
CAS No.	387-66-6
Molecular Formula	C₂₂H₃₀O₅
Molecular Weight	374.47 g/mol
Synonyms	6α-Methylprednisolone; 6α-Methyl-11β,17α,20β,21-tetrahydroxypregna-1,4-diene-3-one; 6α-Methyl-δ¹-prednisolone; 20β-Hydroxy-6α-methylprednisolone; 6α-Methyl-20β-dihydroprednisolone; 11β,17α,20β,21-Tetrahydroxy-6α-methylpregna-1,4-diene-3,20-dione (related form); 6-Methylprednisolone 20β-isomer
EINECS	Contact for details

Quality Control

Our 11β,17α,20β,21-Tetrahydroxy-6α-Methylpregna-1,4-Diene-3-One is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including HPLC for purity, chiral methods for stereochemical confirmation, and residual solvent analysis to ensure it meets stringent specifications for pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with agreed-upon standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.