Description

20-Deoxo-20β-Hydroxy-6α-Methyl Prednisolone is a key synthetic steroid intermediate, specifically a modified prednisolone derivative, valued for its role in the synthesis of more complex and potent corticosteroid APIs. This compound is essential for pharmaceutical R&D and manufacturing, offering a versatile building block for creating anti-inflammatory and immunosuppressive medications. It is primarily required by pharmaceutical manufacturers, research institutions, and fine chemical synthesis companies focused on advanced steroid chemistry.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of high-potency corticosteroid active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry for the development and structural modification of new steroidal drugs with targeted therapeutic effects.
• Process Chemistry: Serves as a standard or reference material for optimizing and scaling up synthetic routes in pilot plants and commercial production.
• Anti-inflammatory Drug Synthesis: A key structural component for creating novel glucocorticoid receptor agonists with improved efficacy and safety profiles.

Basic Information

Product Name	20-Deoxo-20β-Hydroxy-6α-Methyl Prednisolone
CAS No.	387-65-5
Molecular Formula	C₂₂H₃₀O₅
Molecular Weight	374.47 g/mol
Synonyms	6α-Methylprednisolone 17-acetate; 6α-Methyl-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 17-acetate; 20-Deoxo-20-hydroxy-6α-methylprednisolone; 6α-Methylprednisolone 21-acetate (common misnomer); 11β,17α,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 17-acetate; 6α-Methyl-δ¹-prednisolone 17-acetate; 20-Deoxo-20β-hydroxy-6α-methylprednisolone
EINECS	Contact for details

Quality Control

Our 20-Deoxo-20β-Hydroxy-6α-Methyl Prednisolone is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR for identification, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.