Description

6Alpha-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregn-4-Ene-3,20-Dione is a high-purity synthetic steroid intermediate of significant importance in pharmaceutical manufacturing. This compound is valued for its role as a key precursor in the synthesis of potent corticosteroid APIs, enabling the development of advanced anti-inflammatory and immunosuppressive therapies. It is primarily required by pharmaceutical R&D laboratories and fine chemical producers engaged in the synthesis of complex steroid-based drug molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of fluorinated corticosteroid active pharmaceutical ingredients (APIs).
• Corticosteroid Research: Used in laboratory-scale research and development for creating novel steroid derivatives with targeted biological activity.
• Reference Standard: Serves as a high-purity chemical reference standard for analytical method development and quality control in steroid analysis.
• Process Chemistry: Employed in process optimization and scale-up studies within fine chemical and contract manufacturing organizations (CMOs).

Basic Information

Item	Details
Product Name	6Alpha-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregn-4-Ene-3,20-Dione
CAS No.	387-59-7
Molecular Formula	C22H29FO5
Molecular Weight	392.46 g/mol
Synonyms	6α-Fluoro-11β,17,21-trihydroxy-16α-methylpregn-4-ene-3,20-dione; 6α-Fluoroprednisolone; 6α-Fluoro-16α-methylprednisolone; Fluprednisolone; 6-Fluoroprednisolone; 6-Fluoro-16α-methylprednisolone; 6α-Fluoro-16α-methyl-11β,17,21-trihydroxypregn-4-ene-3,20-dione; NSC 47439
EINECS	Contact for details

Quality Control

Our 6Alpha-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregn-4-Ene-3,20-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and specific tests for related substances and residual solvents. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure full traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.