Description

9-Fluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-Methanesulphonate is a high-purity synthetic corticosteroid derivative, specifically the 21-methanesulfonate ester of fluocinolone acetonide. This compound is a critical pharmaceutical intermediate valued for its potent anti-inflammatory and immunosuppressive properties. It is primarily required by manufacturers in the pharmaceutical and life sciences sectors for the research, development, and production of advanced topical and injectable corticosteroid medications.

Application

• Pharmaceutical Intermediate: Key starting material or advanced intermediate in the synthesis of potent corticosteroid APIs, such as fluocinolone acetonide and related analogs.
• Topical Corticosteroid Production: Used in the manufacture of creams, ointments, and solutions for treating severe dermatological conditions like eczema, psoriasis, and contact dermatitis.
• Ophthalmic Formulations: Serves as a precursor for corticosteroids used in eye drops and intravitreal injections to manage inflammation and edema.
• Research & Development: Essential for pharmacological studies, structure-activity relationship (SAR) research, and the development of new anti-inflammatory drugs in academic and industrial labs.
• Veterinary Medicine: Employed in the formulation of anti-inflammatory treatments for animals.
• Reference Standard: Used as a certified reference material (CRM) for quality control and analytical method validation in regulatory compliance testing.

Basic Information

Product Name	9-Fluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-Methanesulphonate
CAS No.	382-66-1
Molecular Formula	C24H31FO8S
Molecular Weight	498.56 g/mol
Synonyms	Fluocinolone Acetonide 21-Methanesulfonate; Fluocinolone Acetonide Mesylate; 6α-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone 21-methanesulfonate; 6α-Fluoro-16α-hydroxyprednisolone 16,17-acetonide 21-methanesulfonate; NSC 92339; Fluocinolone Acetonide 21-(Methylsulfonate); Fluocinolone Acetonide 21-O-Methanesulfonate
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione 21-Methanesulphonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Production can be aligned with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.