Description

9-Fluoro-11Beta-Hydroxy-6Alpha-Methylpregn-4-Ene-3,20-Dione is a synthetic steroid derivative, specifically a fluorinated glucocorticoid precursor. This compound is of significant value in pharmaceutical research and development, serving as a key intermediate in the synthesis of potent corticosteroid drugs. It is primarily needed by pharmaceutical manufacturers and advanced research institutions focused on developing anti-inflammatory and immunosuppressive therapies.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of fluorinated corticosteroid APIs (Active Pharmaceutical Ingredients).
• Anti-inflammatory Drug Research: Used in R&D for developing new glucocorticoid receptor agonists with enhanced potency and metabolic stability.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Biochemical Research: Employed in studies investigating steroid hormone action, receptor binding, and metabolic pathways.
• Process Chemistry: Utilized in scaling up and optimizing manufacturing routes for steroid-based pharmaceuticals.

Basic Information

Product Name	9-Fluoro-11Beta-Hydroxy-6Alpha-Methylpregn-4-Ene-3,20-Dione
CAS No.	378-38-1
Molecular Formula	C22H31FO4
Molecular Weight	378.48 g/mol
Synonyms	6α-Methyl-9α-fluoro-11β-hydroxypregn-4-ene-3,20-dione; 9α-Fluoro-11β-hydroxy-6α-methylpregn-4-ene-3,20-dione; 6α-Methyl-9α-fluoro-11β-hydroxyprogesterone; 9-Fluoro-11β-hydroxy-6α-methylprogesterone; Flumedroxone intermediate; 378-38-1; NSC 121698
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta-Hydroxy-6Alpha-Methylpregn-4-Ene-3,20-Dione is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical intermediate use. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.