Description

Tetramethylammonium Fluoride is a versatile and highly reactive quaternary ammonium salt, primarily valued as a powerful, non-nucleophilic source of fluoride ions. This compound is essential for facilitating challenging desilylation and fluorination reactions in synthetic organic chemistry. It is a critical reagent for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, enabling the synthesis of complex molecules and specialty chemicals.

Application

• Desilylation Agent: A highly effective reagent for the selective cleavage of silicon protecting groups (e.g., TMS, TBDMS) in complex multi-step organic syntheses.
• Fluorination Reactions: Used as a source of naked fluoride ions for nucleophilic aromatic substitution (SNAr) and aliphatic fluorination to introduce fluorine atoms into target molecules.
• Pharmaceutical Intermediate Synthesis: Key reagent in the production of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates where precise fluorination is required.
• Agrochemical Manufacturing: Employed in the synthesis of fluorinated pesticides and herbicides to enhance their biological activity and environmental stability.
• Materials Science: Utilized in the surface modification of silicon-based materials and in the preparation of specialty polymers and electronic chemicals.
• Laboratory Research & Development: A staple in R&D laboratories for method development and exploratory synthesis in medicinal and process chemistry.

Basic Information

Product Name	Tetramethylammonium Fluoride
CAS No.	373-68-2
Molecular Formula	C4H12FN
Molecular Weight	91.14 g/mol
Synonyms	TMAF; N,N,N-Trimethylmethanaminium Fluoride; Tetramethylazanium Fluoride; Ammonium, tetramethyl-, fluoride; Fluorotetramethylammonium; Tetramethylammonium fluoride solution; TMAF Reagent
EINECS	206-765-6

Quality Control

Our Tetramethylammonium Fluoride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including assay, impurity profiling, and moisture content determination, to ensure it meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and must be stored in a cool, dry place, ideally at 2-8°C under an inert atmosphere for long-term stability. Handle and open containers under dry, inert conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or solution
Identification (IR)	Conforms
Assay (Titration)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals (as Pb)	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.