Description

4-Fluoro-3-Nitrotrifluoromethylbenzene is a high-value fluorinated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring both electron-withdrawing nitro and trifluoromethyl groups on a fluorinated benzene ring, makes it a critical intermediate for creating complex molecules with tailored properties. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials, improving dielectric anisotropy and thermal stability.
• Polymer & Resin Modifier: Incorporated to introduce fluorine functionality into polymers, enhancing chemical resistance, lowering surface energy, and improving weatherability.
• Dye & Pigment Intermediate: Employed in the manufacture of specialized, high-performance colorants with improved lightfastness and solubility properties.
• Cross-Coupling Reactions: Acts as a versatile substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.

Basic Information

Product Name	4-Fluoro-3-Nitrotrifluoromethylbenzene
CAS No.	367-82-2
Molecular Formula	C7H2F4NO2
Molecular Weight	208.09 g/mol
Synonyms	1-Fluoro-2-nitro-4-(trifluoromethyl)benzene; 4-Fluoro-3-nitrobenzotrifluoride; 2-Nitro-α,α,α,4-tetrafluorotoluene; α,α,α,4-Tetrafluoro-2-nitrotoluene; 4-(Trifluoromethyl)-2-fluoro-1-nitrobenzene; 2-Fluoro-5-nitrobenzotrifluoride; Benzene, 1-fluoro-2-nitro-4-(trifluoromethyl)-; 367-82-2
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Nitrotrifluoromethylbenzene is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing including GC, HPLC, NMR, and FTIR to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters such as assay and impurity profiles. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and reducing agents. Recommended storage temperature is between 15°C and 25°C. The compound is stable under these conditions for extended periods.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.