Description

2,5-Difluoronitrobenzene is a versatile fluorinated aromatic nitro compound that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable precursor for introducing fluorine atoms into complex molecular architectures, a key strategy in modern pharmaceutical and agrochemical development. This high-purity intermediate is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty materials industries seeking to enhance the metabolic stability, bioavailability, and binding affinity of their target molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of fluorinated active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, anti-cancer agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides where the fluorine moiety improves lipophilicity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a starting material for fluorinated liquid crystal compounds and electron-transport materials in organic light-emitting diodes (OLEDs).
• Polymer Chemistry: Employed in the synthesis of fluorinated monomers and polymers, imparting desirable properties like chemical resistance and low surface energy.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to create complex biaryl and aniline derivatives.
• Dye & Pigment Industry: Intermediate for synthesizing specialized fluorinated dyes and pigments with enhanced color fastness and performance.

Basic Information

Product Name	2,5-Difluoronitrobenzene
CAS No.	364-74-9
Molecular Formula	C6H3F2NO2
Molecular Weight	159.09 g/mol
Synonyms	1,4-Difluoro-2-nitrobenzene; 2,5-Difluoro-1-nitrobenzene; 2-Nitro-1,4-difluorobenzene; Benzene, 1,4-difluoro-2-nitro-; 2,5-Difluoronitrobenzene; 2,5-Difluoronitrobenzol; 2,5-Difluorophenylnitromethane (precursor related); 2,5-Difluoroaniline precursor
EINECS	206-669-5

Quality Control

Our 2,5-Difluoronitrobenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to meet the stringent requirements of fine chemical and cGMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles. We support compliance with global regulatory standards, including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C/59-77°F). Keep away from heat, sparks, open flames, and incompatible materials such as strong reducing agents and bases. The container should be kept upright to prevent leakage.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	32 - 36 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.