Description

4-Bromo-1-Fluoro-2-Nitrobenzene is a versatile halogenated nitrobenzene derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and nitro substituents, makes it a valuable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for the development of active pharmaceutical ingredients (APIs), liquid crystal materials, and functional dyes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds requiring halogenated aromatic cores.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides where the fluorine and nitro groups contribute to biological activity.
• Material Science: Serves as a building block for organic electronic materials, including liquid crystals and organic light-emitting diodes (OLEDs).
• Dye and Pigment Industry: An intermediate in the production of complex, high-performance dyes and pigments.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Nucleophilic Aromatic Substitution: The fluorine and nitro groups activate the ring for substitution reactions, useful for introducing diverse functional groups.
• Research & Development: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Product Name	4-Bromo-1-Fluoro-2-Nitrobenzene
CAS No.	364-73-8
Molecular Formula	C6H3BrFNO2
Molecular Weight	220.00 g/mol
Synonyms	1-Bromo-4-Fluoro-2-Nitrobenzene; 2-Nitro-4-Bromofluorobenzene; 4-Bromo-2-Nitrofluorobenzene; 4-Fluoro-2-Nitrobromobenzene; 2-Fluoro-5-Nitrobromobenzene; p-Bromo-o-nitrofluorobenzene; (4-Bromo-2-nitrophenyl) fluoride
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-Fluoro-2-Nitrobenzene is produced under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of our global clientele in research and manufacturing. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.