Description

2,4-Pentanedione, 1-Fluoro- (6Ci,7Ci,8Ci,9Ci) is a fluorinated derivative of acetylacetone, a versatile β-diketone building block. This compound is valued for its unique reactivity, where the fluorine atom and the diketone moiety create a bifunctional platform for synthesizing complex heterocycles and metal chelates. It is primarily sought by research chemists and process development teams in the pharmaceutical and agrochemical sectors for advanced intermediate synthesis. The compound, with CAS number 352-20-5, is a key reagent for introducing fluorinated motifs into target molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs) and complex heterocyclic compounds.
• Agrochemical Synthesis: Used in the development of novel fluorinated pesticides and herbicides, leveraging fluorine's ability to enhance biological activity and metabolic stability.
• Ligand in Coordination Chemistry: Acts as a chelating agent for various metal ions, forming stable complexes used in catalysis and materials science.
• Organic Synthesis Building Block: Employed in cyclization reactions, such as the synthesis of fluorinated pyrazoles and isoxazoles, which are privileged scaffolds in medicinal chemistry.
• Chemical Research & Development: Utilized in academic and industrial R&D for exploring new fluorination methodologies and reaction pathways.
• Specialty Chemical Manufacturing: A key starting material for producing high-value, performance chemicals with specific fluorinated properties.

Basic Information

Product Name	2,4-Pentanedione, 1-Fluoro- (6Ci,7Ci,8Ci,9Ci)
CAS No.	352-20-5
Molecular Formula	C5H7FO2
Molecular Weight	118.10 g/mol
Synonyms	1-Fluoro-2,4-pentanedione; 1-Fluoroacetylacetone; 1-Fluoro-2,4-dioxopentane; 3-Fluoro-2,4-pentanedione; 3-Fluoroacetylacetone; 3-Fluoropentane-2,4-dione; F-AA; Fluorinated acetylacetone
EINECS	206-523-8

Quality Control

Our 2,4-Pentanedione, 1-Fluoro- is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatography (GC/HPLC) and spectroscopy (NMR, IR), to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with every shipment. We support cGMP and ISO 9001 compliant manufacturing for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat and ignition sources. Due to its highly volatile and light-sensitive nature, it is recommended to store at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. Use appropriate grounding and bonding procedures during handling to prevent static discharge.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.410 - 1.430
Density (20°C)	1.15 - 1.25 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.