Description

3-Chloro-4-Fluoronitrobenzene is a versatile halogenated nitroaromatic compound, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable precursor for the development of active pharmaceutical ingredients (APIs) and high-performance agrochemicals. This intermediate is essential for research and manufacturing chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogen and nitro functionalities into complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key starting material in the synthesis of various active pharmaceutical ingredients (APIs), particularly those containing fluoro- and chloro-substituted aromatic rings.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides, where the nitro group can be further transformed into amines or other functional groups.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for advanced electronic materials, including components for liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Dye and Pigment Manufacturing: Employed in the synthesis of complex dyes and organic pigments due to its reactive nitro and halogen groups.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create biaryl structures for material science applications.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D focused on novel heterocyclic compounds and fluorinated molecules.

Basic Information

Product Name	3-Chloro-4-Fluoronitrobenzene
CAS No.	350-30-1
Molecular Formula	C6H3ClFNO2
Molecular Weight	175.54 g/mol
Synonyms	1-Chloro-2-fluoro-5-nitrobenzene; 2-Fluoro-5-nitrochlorobenzene; 3-Chloro-4-fluoronitrobenzene; 4-Fluoro-3-chloronitrobenzene; 5-Nitro-2-fluoro-1-chlorobenzene; Benzene, 1-chloro-2-fluoro-5-nitro-; 2-Fluoro-5-nitro-1-chlorobenzene
EINECS	206-499-8

Quality Control

Our 3-Chloro-4-Fluoronitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong reducing agents and bases.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	44 - 48 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.