Description

1-Chloro-4-Fluoro-5-Methyl-2-Nitrobenzene is a high-purity, multi-functional halogenated nitrobenzene derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its unique substitution pattern, which provides precise reactivity for constructing complex molecular architectures. This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the chloro-fluoro-nitro motif imparts specific biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of advanced polymers and liquid crystals.
• Dye and Pigment Manufacturing: Acts as an intermediate for producing complex, color-fast azo dyes and other specialty pigments.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig amination, enabling carbon-carbon and carbon-heteroatom bond formation.

Basic Information

Product Name	1-Chloro-4-Fluoro-5-Methyl-2-Nitrobenzene
CAS No.	345-23-3
Molecular Formula	C7H5ClFNO2
Molecular Weight	189.57 g/mol
Synonyms	2-Nitro-4-chloro-5-fluorotoluene; 4-Chloro-5-fluoro-2-nitrotoluene; 5-Methyl-2-nitro-1-chloro-4-fluorobenzene; 1-Chloro-4-fluoro-5-methyl-2-nitrobenzene; 345-23-3; 2-Nitro-4-chloro-α,α,α-trifluorotoluene (related); 4-Chloro-α,α,α-trifluoro-2-nitrotoluene (related)
EINECS	Contact for details

Quality Control

Our 1-Chloro-4-Fluoro-5-Methyl-2-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Ensure the container is kept upright to prevent leakage.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.