Description

5-Chloro-2-Fluoronitrobenzene is a versatile halogenated nitrobenzene derivative that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable precursor for the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. This intermediate is essential for researchers and manufacturers creating active pharmaceutical ingredients (APIs), crop protection agents, and specialty dyes.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds containing benzimidazole or quinazoline scaffolds.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and insecticides, where the chloro and fluoro substituents contribute to biological activity.
• Dye and Pigment Manufacturing: Serves as a starting material for the production of complex organic dyes and pigments.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors.
• Cross-Coupling Reactions: A valuable substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and halogen groups make it an excellent candidate for displacement reactions to introduce diverse functionalities.

Basic Information

Product Name	5-Chloro-2-Fluoronitrobenzene
CAS No.	345-18-6
Molecular Formula	C6H3ClFNO2
Molecular Weight	175.54 g/mol
Synonyms	1-Chloro-4-fluoro-2-nitrobenzene; 4-Fluoro-2-nitrochlorobenzene; 2-Fluoro-5-chloronitrobenzene; 2-Nitro-5-chlorofluorobenzene; 5-Chloro-2-fluoronitrobenzene; 345-18-6; 4-Fluoro-1-chloro-2-nitrobenzene; 5-Chloro-2-fluoro-1-nitrobenzene
EINECS	206-458-5

Quality Control

Our 5-Chloro-2-Fluoronitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	45 - 50 °C
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.