Description

2-Chloro-5-Fluoronitrobenzene is a high-purity halogenated nitrobenzene derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the production of complex molecules, particularly in the pharmaceutical and agrochemical sectors. Industrial buyers and R&D chemists in fine chemical manufacturing need it for its reliable reactivity in substitution and coupling reactions to create active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and pesticides where the chloro-fluoro-nitro substitution pattern is required for bioactivity.
• Dye and Pigment Manufacturing: Serves as an intermediate for producing specialized azo dyes and colorants.
• Liquid Crystal & Electronic Chemicals: A building block for fluorinated liquid crystal compounds and other electronic materials.
• Cross-Coupling Reactions: Used in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Organic Synthesis Research: A valuable reagent in academic and industrial R&D for exploring new synthetic pathways.

Basic Information

Product Name	2-Chloro-5-Fluoronitrobenzene
CAS No.	345-17-5
Molecular Formula	C6H3ClFNO2
Molecular Weight	175.54 g/mol
Synonyms	1-Chloro-4-fluoro-2-nitrobenzene; 4-Fluoro-2-nitrochlorobenzene; 2-Nitro-4-fluorochlorobenzene; 2-Chloro-4-fluoronitrobenzene; 5-Fluoro-2-chloronitrobenzene; Benzene, 2-chloro-1-fluoro-4-nitro-; 2-Chloro-1-fluoro-4-nitrobenzene
EINECS	206-456-6

Quality Control

Our 2-Chloro-5-Fluoronitrobenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive; containers should be opaque or stored in darkness.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	45 - 50 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.