Description

9-Fluoro-11Beta,16Alpha,17,21-Tetrahydroxypregn-4-Ene-3,20-Dione is a synthetic fluorinated corticosteroid derivative, a key intermediate in the synthesis of potent anti-inflammatory pharmaceutical agents. Its precise molecular structure is critical for developing advanced steroid-based therapeutics with targeted activity. This high-purity intermediate is essential for pharmaceutical R&D and manufacturing, particularly for companies specializing in glucocorticoid receptor agonists.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of potent topical and systemic corticosteroids, such as fluocinolone acetonide and related analogs.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the research and scale-up production of novel steroid-based APIs for anti-inflammatory and immunosuppressive therapies.
• Biochemical Research: Used in laboratory studies to investigate glucocorticoid receptor binding, steroid metabolism, and structure-activity relationships (SAR).
• Veterinary Medicine: Potential application in the development of anti-inflammatory treatments for animal health.
• Reference Standard: Employed as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical manufacturing.

Basic Information

Product Name	9-Fluoro-11Beta,16Alpha,17,21-Tetrahydroxypregn-4-Ene-3,20-Dione
CAS No.	337-02-0
Molecular Formula	C21H27FO6
Molecular Weight	394.44 g/mol
Synonyms	9α-Fluoro-11β,16α,17,21-Tetrahydroxypregn-4-ene-3,20-dione; Fluocinolone Acetonide Intermediate; 9α-Fluoro-16α-hydroxyprednisolone; 6α-Fluoro-16α-hydroxyprednisolone (common misnomer); 9-Fluoro-11β,16α,17,21-tetrahydroxy-1,4-pregnadiene-3,20-dione; 16α-Hydroxy-9α-fluoroprednisolone; NSC 92339
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,16Alpha,17,21-Tetrahydroxypregn-4-Ene-3,20-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and stringent control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.