Description

9 α-Fluorocorticosterone is a synthetic fluorinated corticosteroid derivative, a key intermediate in the research and development of potent anti-inflammatory and immunosuppressive agents. Its value lies in the significant biological activity enhancement conferred by the fluorine atom at the 9-alpha position, making it a critical building block for advanced pharmaceutical synthesis. This compound is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on developing novel steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of more potent fluorinated corticosteroid drugs, such as dexamethasone and betamethasone derivatives.
• Biochemical Research: Used as a reference standard and active compound in studies investigating glucocorticoid receptor binding, metabolism, and structure-activity relationships (SAR).
• Steroid Chemistry Development: Serves as a model compound for developing new fluorination techniques and studying the effects of halogenation on steroid potency and pharmacokinetics.
• Veterinary Pharmaceutical R&D: Employed in the research of anti-inflammatory treatments for animals.
• Academic Research: Utilized in university and institutional labs for teaching and advanced studies in medicinal chemistry and endocrinology.

Basic Information

Product Name	9 α-Fluorocorticosterone
CAS No.	336-45-8
Molecular Formula	C21H29FO4
Molecular Weight	364.45 g/mol
Synonyms	9α-Fluorocorticosterone; 9α-Fluoro-11β,21-dihydroxypregn-4-ene-3,20-dione; 9α-Fluoro-11β,21-dihydroxyprogesterone; 9-Fluorocorticosterone; NSC 47439; Fluorohydrocortisone precursor; 9α-Fluoro Reichstein's Substance S
EINECS	Contact for details

Quality Control

Our 9 α-Fluorocorticosterone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development purposes. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.