Description

1,1,1-Trifluoroacetone Cyanohydrin is a versatile fluorinated organic intermediate, primarily valued for its trifluoromethyl group which imparts unique physicochemical properties to final compounds. This compound is essential for the synthesis of advanced agrochemicals and pharmaceuticals, where the introduction of fluorine atoms is a key strategy for enhancing metabolic stability and biological activity. It serves as a critical building block for researchers and manufacturers in fine chemical, agrochemical, and pharmaceutical development.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of advanced herbicides and pesticides, leveraging the trifluoromethyl group for improved efficacy and environmental profile.
• Pharmaceutical Building Block: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for introducing fluorine into molecules to modulate bioavailability and metabolic stability.
• Fine Chemical Synthesis: Serves as a versatile reagent for constructing complex fluorinated molecules in custom synthesis and process development.
• Liquid Crystal & Electronic Materials: Employed in the production of fluorinated components for advanced display technologies and specialty polymers.
• Research & Development: A valuable tool for academic and industrial R&D labs exploring new fluorination methodologies and compound libraries.

Basic Information

Product Name	1,1,1-Trifluoroacetone Cyanohydrin
CAS No.	335-08-0
Molecular Formula	C4H4F3NO
Molecular Weight	139.08 g/mol
Synonyms	1,1,1-Trifluoro-2-hydroxy-2-methylpropanenitrile; 1,1,1-Trifluoroacetone cyanohydrin; 2-Hydroxy-2-methyl-3,3,3-trifluoropropionitrile; 3,3,3-Trifluoro-2-hydroxy-2-methylpropionitrile; Trifluoroacetone cyanohydrin; α-Hydroxy-α-methyl-β,β,β-trifluoropropionitrile; TFACH; Contact for additional trade names.
EINECS	206-387-5

Quality Control

Our 1,1,1-Trifluoroacetone Cyanohydrin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including assay by GC/HPLC, identity confirmation (IR, NMR), and impurity profiling to ensure it meets the high standards required for synthetic applications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.